Royal Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack on an subterranean weapons facility in Syria used by the Daesh militant organization, according to the UK's MoD.
The site, identified by reconnaissance, was thought to be containing munitions and bombs, the announcement noted, and was located in mountainous terrain just north of the ancient city of Palmyra in the heart of Syria.
"The RAF jets used laser-guided Paveway IV weapons to target a number of entry passages providing entry to the depot... initial indications indicate the objective was successfully hit," the MoD said.
There was no evidence of any harm to civilians in the attack late on Saturday and every plane involved returned to base without incident, the MoD added.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
The Islamic State group - alternatively referred to as ISIS - established militant control over significant areas in Syria and Iraq prior to its 2019 collapse.
"This operation underscores our UK leadership, and commitment to operate in unison with our allies, to stamp out any re-emergence of Daesh and their dangerous and violent ideologies in the area," the British Defence Secretary John Healey stated.
British military aircraft have carried out surveillance missions over Syrian airspace to "deter any attempted comeback" of Islamic State after its routing at the Baghuz confrontation in the year 2019, the ministry said.
"I want to thank the personnel of British forces who took part in this strike for their skill and their valour," he said. "They were among a great many British personnel on duty over the holidays. This action, to take out dangerous terrorists who endanger our security, highlights how UK forces are always on standby, continuously, ensuring Britain's security at home and strong abroad."
In December, the US military executed what it described as a "large-scale strike" on Islamic State objectives in the country, subsequent to an attack claimed the lives of two US servicemembers and a local interpreter in the Palmyra area.
The United Nations estimates IS still maintains roughly 5-7 thousand fighters in Iraq and Syria.